Oxocarbazate (Synonyms: Oxocarbazate; CID 23631927; CID23631927; CID-23631927;) |
| カタログ番号GB62275 |
オキソカルバゼートは、CID23631927としても知られており、人間のカテプシンLの阻害剤です。
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Cas No.: 1014405-03-8
Sample solution is provided at 25 µL, 10mM.
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Oxocarbazate, also known as CID23631927, is an inhibitor of human cathepsin L. In the cathepsin L inhibition assay, The oxocarbazate caused a time-dependent 17-fold drop in IC50 from 6.9 nM (no preincubation) to 0.4 nM (4-h preincubation). Slowly reversible inhibition was demonstrated in a dilution assay. CID23631927 demonstrate activity in blocking both SARS-CoV (IC50 = 273 nM) and Ebola virus (IC50 = 193 nM) entry into human embryonic. CID 23631927 was a subnanomolar, slow-binding, reversible inhibitor of human cathepsin L that blocked SARS-CoV and Ebola pseudotype virus entry in human cells. Inhibition of cathepsin L thus holds promise for therapeutic intervention for both SARS-CoV and Ebola virus infection.
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