Palmitoyl Alkyne-Coenzyme A (trifluoroacetate salt) |
| カタログ番号GC44547 |
アシル補酵素A（アシル-CoA）チオエステルは、ミトコンドリアやペルオキシソームにおけるβ-酸化によるエネルギー生産、三酸グリセリド、リン脂質、コレステロールエステルの生合成など、様々な生理学的経路で使用されます。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Acyl coenzyme A (acyl-CoA) thioesters are used by a variety of physiological pathways, including energy production by β-oxidation in mitochondria and peroxisomes and the biosynthesis of triacylglycerols, phospholipids, and cholesterol esters.[1] In addition, palmitoyl CoA serves as a substrate for palmitoylation, a post-translational protein modification in which a protein acyltransferase transfers the palmitoyl group to a free thiol on target proteins. [2] Palmitoyl alkyne-CoA is an ω-alkynylated form of palmitoyl CoA. The terminal alkyne group allows the use of click chemistry linking reactions to label or pull down compounds that interact with palmitoyl CoA or, after palmitoyl transfer, the acyl group. Specifically, palmitoyl alkyne-CoA may be useful in assessing the in vitro palmitoylation of proteins.
Reference:
[1]. Waku, K. Origins and fates of fatty acyl-CoA esters. Biochim. Biophys. Acta. 1124(2), 101-111 (1992).
[2]. Budde, C., Schoenfish, M.J., Linder, M.E., et al. Purification and characterization of recombinant protein acyltransferases. Methods: A Companion to Methods in Enzymology 40(2), 143-150 (2006).
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