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Pam2CSK4 TFA

カタログ番号GC72114

Pam2CSK4 TFAはリポペプチドであり、tlr6非依存的なtlr2リガンドおよびアゴニストである。

Products are for research use only. Not for human use. We do not sell to patients.

Pam2CSK4 TFA 化学構造

サイズ 価格 在庫数 個数
1 mg
$216.00
在庫あり
5 mg
$648.00
在庫あり

Tel:(909) 407-4943 Email: sales@glpbio.com

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    GlpBio Citations
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
Pam2CSK4 (TFA), a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 (TFA) promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 (TFA) also activates iNOS expression and NO production in mouse macrophages.

References:
[1]. Parra-Izquierdo I, et al. The Toll-Like Receptor 2 Ligand Pam2CSK4 Activates Platelet Nuclear Factor-κB and Bruton's Tyrosine Kinase Signaling to Promote Platelet-Endothelial Cell Interactions. Front Immunol. 2021 Aug 30;12:729951.
[2]. Kulsantiwong P, et al. Pam2CSK4 and Pam3CSK4 induce iNOS expression via TBK1 and MyD88 molecules in mouse macrophage cell line RAW264.7. Inflamm Res. 2017 Oct;66(10):843-853.
[3]. Kaur A, et al. An efficient and scalable synthesis of potent TLR2 agonistic PAM2CSK4. RSC Adv. 2018 Mar 5;8(18):9587-9596.

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