PARL-IN-1 |
| カタログ番号GC71203 |
PARL-IN-1 はic50値28 nmの強力なparl阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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PARL-IN-1 (compound 5; 5 nM-20 μM) impedes mitochondrial stress-induced cleavage of PGAM by PARL in cells and inhibits the cleavage of overexpressed human PGAM5 in HEK293T cells in a dose-dependent manner[1].
PARL-IN-1 (0.1-30 μM; 8 h; HEK293T cells) stabilizes PINK1 and triggers its alternative cleavage and trafficking in living cells[1].
PARL-IN-1 (5 μM; 22 h; HEK293 T-REx cells) blocks the respiratory chain leading to aberrant reactive oxygen species (ROS) production, activates the PINK1/Parkin pathway[1].
References:
[1]. Poláchová E, et, al. Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy. J Med Chem. 2023 Jan 12;66(1):251-265.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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