PCTR1 (Synonyms: Protein Conjugates in Tissue Regeneration 1) |
| カタログ番号GC44579 |
PCTR1 は強力な単球/マクロファージ アゴニストであり、細菌感染時の主要な抗炎症および前解決プロセスを調節します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1810710-59-8
Sample solution is provided at 25 µL, 10mM.
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Protectin conjugates in tissue regeneration 1 (PCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is then converted to PCTR1 by glutathione S-transferase. PCTR1 levels increase during resolution of acute microbial-induced peritonitis in mice. PCTR1 (30 ng, i.p.) administration 12 hours post-infection increases macrophage numbers and activity and shortens the resolution phase of inflammation by 57%. It also reduces the levels of PGE2 , PGD2 , and TXB2 in peritoneal exudates.
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