PDK1-IN-RS2 |
| カタログ番号GC66474 |
PDK1-IN-RS2 は、ペプチド ドッキング モチーフ (PIFtide) の模倣体であり、Kd が 9 μM の基質選択的 PDK1 阻害剤です。 PDK1-IN-RS2 は、PDK1 による下流のキナーゼ S6K1 の活性化を抑制します。
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Cas No.: 1643958-89-7
Sample solution is provided at 25 µL, 10mM.
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PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1[1].
PDK1-IN-RS2 stimulates the catalytic activity of PDK1 toward a peptide substrate by sixfold. The sulfonyl group of PDK1-IN-RS2 interacts with Arg131 through a salt bridge, because the sulfonamide is likely ionized under the crystallization conditions[1].
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