Pentosan Polysulfate Sodium (W/W 43%) |
カタログ番号GC61171 |
ペントサン ポリ硫酸ナトリウムは、抗炎症作用と軟骨形成促進作用を備えた、経口で生物学的に利用可能な半合成医薬品です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 140207-93-8
Sample solution is provided at 25 µL, 10mM.
Pentosan Polysulfate Sodium is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also is a potent and selective anti-HIV agent. Pentosan Polysulfate Sodium is used for the treatment of interstitial cystitis[1][2][3].
Pentosan Polysulfate Sodium has been shown to inhibit HIV-1 activity with an ED50 of 0.19 μg/mL in MT-4 cells. It inhibits HIV-1 antigen expression in HUT-78 cells at an ED50 of 0.02 μg/mL, and complete inhibition of HIV-1 antigen expression is obtained at a concentration of 4.0 μg/mL[2].Pentosan Polysulfate Sodium suppresses NF-κB, decreases the proinflammatory actions of TNFα, and decreases high glucose and advanced glycation end products (AGEs) stimulated MCP-1 production[3].
Pentosan Polysulfate Sodium has been shown to decreases interstitial inflammation and glomerulosclerosis in 5/6 nephrectomized rats. Pentosan polysulfate treatment preserves renal function, significantly reduces albuminuria, and markedly decreases the severity of renal lesions, including tubulointerstitial inflammation. Pentosan Polysulfate Sodium also reduces upregulation of TNFα and proinflammatory genes in aging diabetic kidneys[3].
[1]. Schuchman EH, et al. Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses. PLoS One. 2013;8(1):e54459. [2]. Baba M, et al. Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro. Antiviral Res. 1988 Sep;9(6):335-43. [3]. Wu J, et al. Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice. Lab Invest. 2011 Oct;91(10):1459-71.
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