PF 3084014 hydrobromide (Synonyms: PF-3084014 dihydrobromide; PF-03084014 dihydrobromide) |
| カタログ番号GC50251 |
PF 3084014 臭化水素酸塩 (PF-3084014 二臭化水素酸塩) は可逆的で、経口で生物学的に利用可能で、非競合的で、選択的な γ-セクレターゼ阻害剤であり、IC50 は 6.2 nM です。胃腸毒性を最小限に抑えながら、PF 3084014 臭化水素酸塩による Notch シグナル伝達の阻害は、Notch 受容体依存性癌の研究に有望なアプローチを提示します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1962925-29-6
Sample solution is provided at 25 µL, 10mM.
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Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.
Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269 PMID:20363853
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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