PF-3450074 (Synonyms: PF74) |
| カタログ番号GC39664 |
PF-3450074 (PF-74) は、HIV-1 キャプシドタンパク質 (CA) の特異的阻害剤であり、サブマイクロモルの効力 (EC50=8-640 nM) で HIV 分離株の広域スペクトル阻害を示します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1352879-65-2
Sample solution is provided at 25 µL, 10mM.
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PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle[1][2]. CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.
[1]. Xu JP, et al. Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action.J Drug Des Res. 2018;5(2). pii: 1070. Epub 2018 Aug 13. [2]. Shi J, et al. Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization.J Virol. 2011 Jan;85(1):542-9.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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