PF-739 |
| カタログ番号GC70439 |
PF-739はAMPKの経口活性非選択的活性剤である。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1852452-14-2
Sample solution is provided at 25 µL, 10mM.
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PF-739 activates α2β1γ1, α2β2γ1, α1β1γ1 and α1β2γ1 with EC50 values of 5.23 nM, 42.2 nM, 8.99 nM and 126 nM, respectively[1].
PF-739 (0-1000 nM) increases the phosphorylation of AMPK substrate in primary rat hepatocytes and myotubes of primary human cardiac cell line with dose-dependent manner[2].
PF-739 (30-1000 mg/kg; p.o. or s.c.; single does) effectively activates AMPK in liver cells and skeletal muscle and reduces plasma glucose level in C57BL/6 mice[2].
References:
[1]. Aledavood E, et al. Elucidating the Activation Mechanism of AMPK by Direct Pan-Activator PF-739[J]. Frontiers in Molecular Biosciences, 2021, 8: 760026.
[2]. Cokorinos EC, et al. Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice. Cell Metab. 2017 May 2;25(5):1147-1159.e10.
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