PHOP (Synonyms: CAY10402, Phenyl hexanoyl oxazolopyridine) |
| カタログ番号GC40955 |
脂肪酸アミド加水分解酵素（FAAH）は、アナンダミドやオレアミドを含む脂肪酸アミドの加水分解と不活性化に責任がある酵素です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 288862-83-9
Sample solution is provided at 25 µL, 10mM.
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Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. PHOP is a potent FAAH inhibitor, exhibiting Ki values of 0.094 nM and 0.2 nM for the human and rat enzymes, respectively. Using a proteomics approach, PHOP was screened against the serine hydrolase family of enzymes, of which FAAH is a member. In this assay, PHOP exhibited IC50 values of 1.1 nM, 1.4 nM, and >100 µM for FAAH, triacylglycerol hydrolase (TGH), and an uncharacterized hydrolase (KIAA1363), respectively. Knowledge of the specificity of PHOP obtained from this experiment should allow for more accurate interpretation of results using this inhibitor in complex environments such as whole cells or animals.
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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