PLC thio-PIP2 (sodium salt) |
| カタログ番号GC44661 |
リン脂質分解酵素C（PLC）は、細胞膜の細胞質側でホスファチジルイノシトール（4,5）ビスリン酸（PIP2）を加水分解して、ジアシルグリセロールとイノシトール-1,4,5-トリスリン酸（IP3）を生成します。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Phospholipase C (PLC) catalyzes the hydrolysis of phosphatidylinositol (4,5) bisphosphate (PIP2) on the cytoplasmic side of the cell membrane to yield diacylglycerol and inositol-1,4,5-triphosphate (IP3). This reaction initiates a well-known signal transduction pathway common to most cells. PLC thio-PIP2 is an analog of naturally occurring PIP2 that contains sulfur rather than oxygen at the sn-3 position of the glycerol backbone. Hydrolysis by PLC yields a free thiol which reacts with chromogenic reagents such as DTNB (Ellman's reagent) to allow quantitation of PLC activity.
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