PLX 647 dihydrochloride |
| カタログ番号GC50099 |
PLX 647 二塩酸塩は、経口で活性な、特異性の高いデュアル FMS および KIT キナーゼ阻害剤であり、IC50 はそれぞれ 28 および 16 nM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1779796-38-1
Sample solution is provided at 25 µL, 10mM.
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Potent dual KIT/Fms inhibitor (IC50 values are 16 and 28 nM respectively). Inhibits BCR-FMS cell proliferation and osteoclast differentiation in vitro (IC50 values are 92 and 170 nM respectively). Attenuates LPS-induced TNFα and IL-6 release, mast cell activation and macrophage kidney proliferation in vivo.
Zhang et al (2013) Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc.Natl.Acad.Sci.U.S.A. 110 5689 PMID:23493555
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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