PNU112455A hydrochloride |
| カタログ番号GC39421 |
PNU112455A 塩酸塩は、ATP 競合 CDK2 および CDK5 阻害剤です。 PNU112455A 塩酸塩は、それぞれ 3.6 および 3.2 μM の Kms で CDK2 および CDK5 の ATP 部位に結合します。
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Cas No.: 21886-12-4
Sample solution is provided at 25 µL, 10mM.
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PNU112455A hydrochloride is an ATP-competitive CDK2 and CDK5 inhibitor. PNU112455A hydrochloride binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively[1].
[1]. Clare PM, et al. The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism. J Biol Chem. 2001 Dec 21;276(51):48292-9.
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