POM 1 (Synonyms: Sodium Metatungstate, Sodium Polyoxotungstate) |
| カタログ番号GC17027 |
POM 1 (ポリオキソタングステン酸ナトリウム) は強力なエクトヌクレオシド三リン酸ジホスホヒドロラーゼ (ENTPDase) 阻害剤であり、Ki 値は 2.58 μM、3.26 μM、NTPDase 1 (CD39)、NTPDase 1 (CD39) では 28.8 μM です。それぞれ。
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Cas No.: 12141-67-2
Sample solution is provided at 25 µL, 10mM.
Sodium metatungstate (POM-1) is a potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively[1]. Sodium metatungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition[2].
References:
[1]. Müller CE, et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5943-7.
[2]. Wall et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology. 2008 Dec;55(7):1251-8.
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