PQ 69 |
カタログ番号GC50149 |
PQ 69 は、逆アゴニスト活性を持つ強力かつ選択的なアデノシン A1 受容体アンタゴニストです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 910045-32-8
Sample solution is provided at 25 µL, 10mM.
Potent and selective A1 receptor inverse agonist. Exhibits high binding affinity at A1 receptor (Ki values are 0.07 and 0.96 nM for rat and human receptors respectively). Reduces basal [35S]-GTPγS binding 44.6% (IC50 = 0.19 nM). Antagonizes the effects of A1 agonist R-PIA (IC50 = 18.3 nM) and exhibits competitive antagonism on CCPA-induced tracheal contractions ex vivo. Displays 217- fold selectively over hA2A receptor and >1000-fold selectivity over hA3 receptor.
Lu et al (2014) PQ-69, a novel and selective adenosine A1 receptor antagonist with inverse agonist activity. Purinergic Signal. 10 619 PMID:25248972
Average Rating: 5
(Based on Reviews and 27 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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