Pravadoline |
| カタログ番号GC44675 |
プラバドリンは、シクロオキシゲナーゼを抑制する非酸性のアミノアルキルインドール系鎮痛剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 92623-83-1
Sample solution is provided at 25 µL, 10mM.
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Pravadoline is a nonacidic, aminoalkylindole analgesic agent that inhibits cyclooxygenase. Like NSAIDs, pravadoline inhibits prostaglandin synthesis (IC50 = 5 μM in mouse brain microsomes) and displays antinociceptive activity (ED50 = 26 mg/kg in an acetylcholine-induced writhing assay in mice). In contrast to NSAIDs, pravadoline inhibits neuronally stimulated contractions in mouse vas deferens preparations (IC50 = 0.45 μM), an effect similar to that which is produced by opioid analgesics, yet is not attenuated by the opioid receptor antagonist, naloxone. Pravadoline does not produce gastrointestinal irritation following acute or chronic administration to rodents.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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