[Pro3]-GIP (Mouse) |
| カタログ番号GC50278 |
GIP受容体拮抗剤
Products are for research use only. Not for human use. We do not sell to patients.
![[Pro3]-GIP (Mouse) 化学構造](/media/struct/GC5/GC50278.png "[Pro3]-GIP (Mouse) 化学構造")
Sample solution is provided at 25 µL, 10mM.
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GIP receptor antagonist (IC50 = 2.6μM). Inhibits GIP-stimulated insulin release from pancreatic β cells in vitro. In ob/ob mice, blocks the effects of GIP on insulin release and plasma glucose levels. Also improves intraperitoneal glucose tolerance, insulin sensitivity, and glucose response to feeding in ob/ob mice.
Irwin et al (2007) Early administration of the glucose-dependent Insotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. Diabetologia 50 1532 PMID:17486314 |Gault et al (2002) Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent Insotropic polypeptide. Biochem.Biophys.Res.Commun. 290 1420 PMID:11820780
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