Propargyl-PEG3-phosphonic acid diethyl ester |
| カタログ番号GC67239 |
プロパルギル-PEG3-ホスホン酸ジエチルエステルは、PROTACの合成に使用できるPEGベースのPROTACリンカーです。
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Cas No.: 1052678-30-4
Sample solution is provided at 25 µL, 10mM.
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Propargyl-PEG3-phosphonic acid diethyl ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Thorsten Heidelberg, et al. Oligo-ethylene glycol based phosphonate surface modification reagents and use thereof. WO2015065168A1
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