Prostaglandin A3 (Synonyms: PGA3) |
| カタログ番号GC40765 |
EPAのシクロオキシゲナーゼ代謝によってプロスタグランジンE3（PGE3）が生成されることは、羊精嚢の生合成準備および霊長類の眼組織で報告されています。
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Cas No.: 36614-31-0
Sample solution is provided at 25 µL, 10mM.
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Cyclooxygenase metabolism of EPA to produce Prostaglandin E3 (PGE3) has been reported in biosynthetic preparations of ovine seminal vesicles and in the ocular tissues of primates. Prostaglandin A3 (PGA3) is an expected non-enzymatic dehydration product of this PGE3. PGA3 exhibits good affinity for the canine EP2 and EP4 receptors with IC50 values of 120 nM and 20 nM, respectively, in a radioligand binding assay. PGA3 has weak affinity for human PPARγ, with a Ki value of 188 µM.
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