Prostaglandin D2-1-glyceryl ester (Synonyms: PGD21glyceryl ester) |
| カタログ番号GC44710 |
2-アラキドノイルグリセロールは豚脳から単離され、CB1受容体の自然なエンドカンナビノイドリガンドとして特徴付けられています。
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Cas No.: 309260-52-4
Sample solution is provided at 25 µL, 10mM.
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2-Arachidonoyl glycerol has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor. Incubation of 2-AG with COX-2 and specific prostaglandin H2 isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation. The biosynthesis of PGH, PGD, PGE, PGF, and TXA-2-glyceryl ester compounds have all been documented. In RAW 264.7 cells, PGD2-2-glyceryl ester is the main COX metabolite. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 mixture of the 1- and 2-glyceryl esters in typical aqueous media. While the stability and metabolism of these PG products have been investigated, little is known about their intrinsic biological activity.
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