Prostaglandin F2α ethyl amide (Synonyms: Dinoprost ethyl amide, PGF2αNEt) |
| カタログ番号GC44723 |
プロスタグランジンF2αエチルアミド（PGF2α-NEt）は、C-1カルボキシル基がN-エチルアミドに修飾されたPGF2αの類似体です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 54130-36-8
Sample solution is provided at 25 µL, 10mM.
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Prostaglandin F2α ethyl amide (PGF2α-NEt) is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-ethyl amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that PG ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 µg/g corneal tissue/hr. PGF2α-NEt would be expected to show the typical intraocular effects of PGF2α free acid, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.
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