R-IMPP (Synonyms: PF-00932239) |
| カタログ番号GC32456 |
R-IMPP (PF-00932239) は PCSK9 の抗分泌促進物質 (IC50=4.8 μM) で、80S リボソームを標的として PCSK9 タンパク質の翻訳を阻害します 。
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Cas No.: 2133832-83-2
Sample solution is provided at 25 µL, 10mM.
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R-IMPP is an inhibitor of PCSK9 secretion.
R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin. R-IMPP does not decrease PCSK9 transcription or increase PCSK9 degradation, but causes transcript-dependent inhibition of PCSK9 translation. R-IMPP is able to selectively bind to human, but not E. coli, ribosomes[1].
[1]. Petersen DN, et al. A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation. Cell Chem Biol. 2016 Nov 17;23(11):1362-1371
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