(R)-TTBK1-IN-1 |
カタログ番号GC70719 |
(R)-TTBK1-IN-1は、強力で選択的で脳透過性のあるtau微小管タンパク質キナーゼ1 TTBK 1阻害剤である。
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Cas No.: 2735015-59-3
Sample solution is provided at 25 µL, 10mM.
(R)-TTBK1-IN-1 is a potent, selective and brain-penetrant tau tubulin kinase 1 (TTBK1) inhibitor. (R)-TTBK1-IN-1 is an enantiomer of TTBK1-IN-1 . (R)-TTBK1-IN-1 can be used in the research of alzheimer’s disease and related tauopathies. (R)-TTBK1-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
References:
[1]. Halkina T, et, al. Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J Med Chem. 2021 May 13;64(9):6358-6380.
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