rac-CCT 250863 |
| カタログ番号GC50063 |
rac-CCT 250863 (化合物 rac-21) は、IC50 が 0.073 μM の選択的かつ可逆的な NEK 2 阻害剤です。 rac-CCT 250863 は、細胞周期の停止を誘導する優れた効果を示し、細胞内で抗増殖性を示すこともできます (ポマリドマイド感受性/耐性)。 rac-CCT 250863 は、ポマリドマイドと組み合わせるとアポトーシスを誘導します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1364269-06-6
Sample solution is provided at 25 µL, 10mM.
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Potent Nek2 inhibitor (IC50 = 73 nM). Exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.
Innocenti et al (2012) Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J.Med.Chem. 55 3228 PMID:22404346
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)
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