(Rac)-Lys-SMCC-DM1 (Synonyms: (Rac)-Lys-Nε-MCC-DM1) |
| カタログ番号GC64069 |
(Rac)-Lys-SMCC-DM1 ((Rac)-Lys-Nε-MCC-DM1) は、Lys-SMCC-DM1 のラセミ体です。 Lys-SMCC-DM1 は、チューブリン重合を阻害する可能性のあるリンカー ペイロード コンポーネントです。 Lys-SMCC-DM1 は、T-DM1 の活性代謝物です。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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(Rac)-Lys-SMCC-DM1 ((Rac)-Lys-Nε-MCC-DM1) is the racemate of Lys-SMCC-DM1 . Lys-SMCC-DM1 is a linker-payload component that has the potential to inhibit tubulin polymerization. Lys-SMCC-DM1 is the active metabolite of T-DM1[1].
[1]. Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46.
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