(2S)-Octyl-α-hydroxyglutarate (Synonyms: (2S)-Octyl-2-HG) |
| カタログ番号GC19473 |
(2S)-オクチル-α-ヒドロキシグルタレート ((2S)-オクチル-2-HG) は、S-異性体 2-ヒドロキシグルタレートの修飾型です。
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Cas No.: 1391194-64-1
Sample solution is provided at 25 µL, 10mM.
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(2S)-Octyl-α-hydroxyglutarate ((2S)-Octyl-2-HG) is a modified form of S-isomer 2-Hydroxyglutarate.
Treatment of IDH1-WT HeLa cells with (2S)-Octyl-α-hydroxyglutarate, a modified form of 2-Hydroxyglutarate with high cellular uptake, results in a dose-dependent increase in DSBs in log-phase cells[1].
Reference:
[1]. Sulkowski PL, et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologousrecombination and induces PARP inhibitor sensitivity. Sci Transl Med. 2017 Feb 1;9(375).
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