3-Hydroxybutyric acid (Synonyms: 3-Hydroxybutyric Acid, NSC 3806, βOHB) |
| カタログ番号GC30616 |
3-ヒドロキシ酪酸 (β-ヒドロキシ酪酸) は、I 型糖尿病で上昇する代謝産物です。
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Cas No.: 300-85-6
Sample solution is provided at 25 µL, 10mM.
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3-Hydroxybutyric acid (D-β-hydroxybutyrate, BHB) is an endogenous and specific inhibitor of histone deacetylase (HDAC). The IC50 for inhibiting HDAC1, HDAC3 and HDAC4 is respectively 5.3, 2.4 and 4.5 mM[1]. 3-Hydroxybutyric acid is a ketone body that can interact with lipids and also reduce the interfacial viscosity of the DPPC monolayer [2]. 3-Hydroxybutyric acid blocks the NLRP3 inflammasome and does not undergo oxidation in the TCA cycle [3].
In vitro, histone H3K9 acetylation at the Foxo3a and Mt2 promoters increased after HEK293 cells were treated with 3-hydroxybutyrate (10 mM) for 24 hours [1]. After treating human monocytes for 24 hours, 3-hydroxybutyric acid (1-20 mM) dose-dependently inhibits the production of interleukin IL-1β and IL-18 mediated by the NLRP3 inflammasome [3]. 3-Hydroxybutyric acid (10 mM) treated mouse glial cells for 48 hours, which significantly promoted cell proliferation [4].
In vivo, 3-hydroxybutyrate (2mM or 5mM) administered to C57BL/6 mice via intracerebroventricular injection can reduce the binding of HDAC2 and HDAC3 to the pI promoter of Bdnf [5]. Intraperitoneal injection of 3-hydroxybutyric acid (5.0 mmol/kg) into suckling mice after hypoxia-ischemia treatment can reduce the number of TUNEL-positive cells in the brain area, reduce cerebral infarction, and thereby reduce brain damage [6].
References:
[1] Shimazu T , Hirschey M D , Newman J ,et al. Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor[J]. Science, 2013, 339(6116):211-4.
[2] Hsu TT, et al. 3-Hydroxybutyric acid interacts with lipid monolayers at concentrations that impair consciousness[J]. Langmuir. 2013 Feb 12;29(6):1948-55.
[3] Youm Y H , Nguyen K Y , Grant R W ,et al. The ketone body β-hydroxybutyrate blocks the NLRP3 inflammasome-mediated inflammatory disease[J]. Nature Medicine, 2015.
[4] Xiao X Q , Zhao Y , Chen G Q .The effect of 3-hydroxybutyrate and its derivatives on the growth of glial cells[J].Biomaterials, 2007, 28(25):3608-3616.
[5]Sleiman S F , Jeffrey H , Rami A H ,et al. Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate[J].Elife, 2016.
[6]Lee B , Woo D C , Woo C W ,et al.Exogenous β-Hydroxybutyrate Treatment and Neuroprotection in a Suckling Rat Model of Hypoxic-Ischemic Encephalopathy[J].Dev Neurosci, 2018.
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