5,6-dihydro-5-Fluorouracil (Synonyms: 5-DHFU, 5-Fluorodihydropyrimidine-2,4-dione, 5-Fluorodihydrouracil, 5-Fluoro-5,6-dihydrouracil, 5-FUH2) |
| カタログ番号GC18542 |
5,6-ジヒドロ-5-フルオロウラシル（5-FUH2）は、酵素であるジヒドロピリミジンデヒドロゲナーゼ（DPD）によって、5-フルオロウラシルの水素化によって形成されます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 696-06-0
Sample solution is provided at 25 µL, 10mM.
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5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil via the enzyme dihydropyrimidine dehydrogenase (DPD). Formulations containing 5-FU are used for the treatment of cancer. However, in patients lacking full DPD activity, severe adverse events, including death, can occur. 5-FUH2 is less toxic than 5-FU but is not as effective (IC50s = 3.3 and 560 uM for 5-FU and 5-FUH2, respectively in WiDr human colon cancer cells).
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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