Agnuside |
| カタログ番号GC40750 |
Agnuside は Vitex negundo から分離された化合物で、炎症誘発性メディエーターである PGE2 および LTB4 をダウンレギュレートし、サイトカインの発現を低下させ、抗関節炎活性を示します 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 11027-63-7
Sample solution is provided at 25 µL, 10mM.
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Agnuside is an iridoid glycoside originally isolated from V. rotundifolia fruit that has diverse biological activities. It inhibits COX-2 with an IC50 value of 0.026 mg/ml but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively. Agnuside (0.1-10 μM) induces proliferation of MCF-7 breast cancer cells, an effect that is inhibited by the estrogen receptor antagonist fulvestrant . In vivo, agnuside (50 mg/kg) reduces acetic acid-induced writhing in mice indicating analgesia. It also suppresses production of the pro-inflammatory mediators prostaglandin E2 (PGE2) and leukotriene B4 and the T cell-mediated cytokines IL-2, TNF-α, INF-γ, IL-4, IL-10, and IL-17 in splenocytes and arthritic paw tissue from arthritic adrenalectomized rats.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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