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Anle138b

カタログ番号GC30846

オリゴマー凝集阻害剤である Anle138b は、プリオンタンパク質 (PrPSc) および α-シヌクレイン (α-syn) の病的な凝集体の形成をブロックします。

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Anle138b 化学構造

Cas No.: 882697-00-9

サイズ 価格 在庫数 個数
10mM (in 1mL DMSO)
$67.00
在庫あり
5mg
$61.00
在庫あり
10mg
$101.00
在庫あり
25mg
$220.00
在庫あり
50mg
$386.00
在庫あり
100mg
$681.00
在庫あり
200mg
$1,195.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description Protocol Chemical Properties Product Documents Related Products

Anle138b is a novel oligomer modulator.

Oligomeric aggregates are presumed to be the key neurotoxic agent. Anle138b blocksthe formation of pathological aggregates of prion protein and of α-synuclein, which is deposited in Parkinson's disease and other synucleinopathies such as dementia with Lewy bodies and multiple system atrophy. Anle138b strongly inhibits all prion strains tested including BSE-derived and human prions. Anle138b shows structure-dependent binding to pathological aggregates and strongly inhibits formation of pathological oligomers both for prion protein and α-synuclein[1].

Anle138b has no detectable toxicity at therapeutic doses and an excellent oral bioavailability and blood-brain-barrier penetration. In mouse models of prion disease and in three different PD mouse models, anle138b strongly inhibits oligomer accumulation, neuronal degeneration, and disease progression[1]. Di-phenyl-pyrazole anle138b binds to aggregated tau and inhibits tau aggregation. Anle138b treatment effectively ameliorates disease symptoms, increases survival time and improves cognition of tau transgenic PS19 mice[2].

[1]. Wagner J, et al. Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol. 2013 Jun;125(6):795-813. [2]. Wagner J, et al. Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies. Acta Neuropathol. 2015 Nov;130(5):619-31.

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