Benzyl butyl phthalate |
| カタログ番号GC60636 |
フタル酸エステル (PAE) のメンバーであるフタル酸ベンジル ブチルは、Zeb1 のアップレギュレーションを介して血管腫 (HA) 細胞の移動と浸潤を引き起こす可能性があります。ベンジル ブチル フタル酸は、乳癌細胞のアリール炭化水素受容体 (AhR) を活性化して SPHK1/S1P/S1PR3 シグナル伝達を刺激し、転移開始乳癌幹細胞 (BCSC) の形成を促進します。
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Cas No.: 85-68-7
Sample solution is provided at 25 µL, 10mM.
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Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs)[1][2][3].
Benzyl butyl phthalate (BBP) is commonly added during the manufacturing of plastics to increase flexibility and elasticity[1].Benzyl butyl phthalate induces histone modifications in S1PR3 in side population (SP) cells, but not in non-SP cells[3].
[1]. Sun G, et al. Developmental toxicity and cardiac effects of butyl benzyl phthalate in zebrafish embryos. Aquat Toxicol. 2017;192:165-170. [2]. Cui S, et al. Benzyl butyl phthalate (BBP) triggers the migration and invasion of hemangioma cells via upregulation of Zeb1. Toxicol In Vitro. 2019;60:323-329. [3]. Wang YC, et al. Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling. Oncotarget. 2016;7(20):29563-29576.
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