BMS-986020 (Synonyms: AM-000152) |
| カタログ番号GC19078 |
BMS-986020 (AM152) は、高親和性で選択的なリゾホスファチジン酸受容体 1 (LPA1) アンタゴニストです 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1257213-50-5
Sample solution is provided at 25 µL, 10mM.
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BMS-986020 is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist[1]. BMS-986020 inhibits bile acid and phospholipid transporters with IC50s of 4.8 µM, 6.2 µM, and 7.5 µM for BSEP, MRP4, and MDR3, respectively[2]. BMS-986020 is used for the treatment of idiopathic pulmonary fibrosis (IPF) [3].
References:
[1]. Kihara Y, et al. Lysophospholipid receptors in drug discovery. Exp Cell Res. 2015 May 1;333(2):171-7.
[2]. Glenn Rosen, et al. LPA1 antagonists BMS-986020 and BMS-986234 for idiopathic pulmonary fibrosis: Preclinical evaluation of hepatobiliary homeostasis. European Respiratory Journal.
[3]. Palmer SM, et al. Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial of BMS-986020, a Lysophosphatidic Acid Receptor Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis. Chest. 2018 Nov;154(5):1061-1069.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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