CARM1-IN-1 hydrochloride |
カタログ番号GC34424 |
CARM1-IN-1 塩酸塩は、IC50 が 8.6 uM の強力で特異的な CARM1 (コアクチベーター関連アルギニンメチルトランスフェラーゼ 1) 阻害剤です。 PRMT1 および SET7 に対して非常に低い活性を示します (IC50 > 600 uM)。
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Cas No.: 2070018-31-2
Sample solution is provided at 25 µL, 10mM.
CARM1-IN-1 hydrochloride is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM). IC50 value: 8.6 uM [1]Target: CRAM1 inhibitorin vitro: CARM1-IN-1 displays high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, CARM1-IN-1 shows a significant dose-dependent reduction of the PSA promoter activity.
[1]. Cheng D, et al. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32.
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