CAY10471 (Synonyms: TM30089) |
| カタログ番号GC18811 |
CAY10471 (TM30089) は、強力で選択的な経口活性プロスタグランジン D2 受容体 CRTH2 アンタゴニストです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 627865-18-3
Sample solution is provided at 25 µL, 10mM.
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The biological effects of prostaglandin D2 are transduced by at least two 7-transmembrane G-protein coupled receptors, designated DP1 and CRTH2/DP2. BAY-u3405 (Ramatroban) is an approved human medication for the treatment of allergic rhinitis that has documented activity as an antagonist of both the TP and CRTH2/DP2 receptors. CAY10471 is an analog of BAY-u3405 which contains modifications that increase both its potency and selectivity for the human CRTH2/DP2 receptor. CAY10471 binds to the human CRTH2/DP2, DP1, and TP receptors with Ki values of 0.6, 1200, and >10,000 nM, respectively.
Review for CAY10471
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
Review for CAY10471
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