CAY10662 |
| カタログ番号GC18879 |
17(R),18(S)-エポキシエイコサテトラエノイン酸（17(R),18(S)-EpETE）は、アイコサペンタエン酸の自然なシトクロムP450エポキシゲナーゼ代謝物質であり、自発的に拍動する心細胞の収縮率を低下させ、β-アドレナリン作動薬による不整脈から新生ラット心筋細胞を保護することが知られています（EC50 =〜1-2 nM）。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1184844-74-3
Sample solution is provided at 25 µL, 10mM.
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17(R),18(S)-Epoxyeicosatetraenoic acid (17(R),18(S)-EpETE), a natural cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid, is known to reduce the contraction rate of spontaneously beating heart cells and to protect neonatal rat cardiomyocytes against arrhythmias induced by β-adrenergic agonists (EC50 = ~ 1-2 nM). CAY10662 is a 1,3 disubstituted urea derivative of 17(R),18(S)-EpETE that is more metabolically robust and reduces the contractility of cardiomyocytes with improved potency (EC50 fold higher than required for the effect on cardiomyocytes, 1-5 μM CAY10662 exerts weak dose-dependent soluble epoxide hydrolase inhibition.
Review for CAY10662
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
Review for CAY10662
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