CCG-232601 |
| カタログ番号GC43212 |
CCG-232601 (化合物 8f) は、経口で有効な強力な Rho/MRTF/SRF 転写経路阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1922099-21-5
Sample solution is provided at 25 µL, 10mM.
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CCG-232601 is an inhibitor of the Rho/MRTF/SRF transcriptional pathway and a derivative of CCG-203971 . CCG-232601 inhibits MRTF-dependent transcription in HEK293T cells (IC50 = 0.55 µM in a luciferase reporter assay). It also reduces expression of α-smooth muscle actin (α-SMA) in TGF-β-stimulated human dermal fibroblasts to 31% of control when used at a concentration of 10 µM. CCG-232601 (50 mg/kg) inhibits increases in dermal thickness and hydroxyproline content in a mouse model of dermal fibrosis induced by bleomycin .
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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