DY 268 |
| カタログ番号GC46012 |
DY 268 は、ファルネソイド X 受容体 (FXR) 拮抗薬です (時間分解 FRET アッセイで IC50 = 7.5 nM)。
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Cas No.: 1609564-75-1
Sample solution is provided at 25 µL, 10mM.
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DY 268 is a farnesoid X receptor (FXR) antagonist (IC50 = 7.5 nM in a time-resolved FRET assay).[1] It inhibits FXR transactivation in a cell-based assay with an IC50 value of 468 nM.
Reference:
[1]. Yu, D.D., Lin, W., Forman, B.M., et al. Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg. Med. Chem. 22(11), 2919-2938 (2014).
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