FK962 |
カタログ番号GC38911 |
FK962 は、ソマトスタチン放出のエンハンサーであり、認知増強作用を発揮します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 283167-06-6
Sample solution is provided at 25 µL, 10mM.
FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions[1].
FK962 (1 nM-1 μM) significantly enhances high K+-evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp[1].
FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease[2]. Animal Model: Male Lister Hooded rats, weighing approximately 270-300[2]
[1]. Tokita K, et al. FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats. Eur J Pharmacol. 2005 Dec 19;527(1-3):111-20. [2]. McCarthy AD, et al. FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease. Pharmacol Biochem Behav. 2011 Mar;98(1):76-80.
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