GAK inhibitor 49 hydrochloride |
| カタログ番号GC61509 |
GAK インヒビター 49 塩酸塩は、0.54 nM の Ki と 56 nM の細胞 IC50 を持つ強力な ATP 競合性および選択性の高いサイクリン G 関連キナーゼ (GAK) インヒビターです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2930378-91-7
Sample solution is provided at 25 µL, 10mM.
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GAK inhibitor 49 hydrochloride is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 hydrochloride also shows binding to RIPK2[1].
GAK inhibitor 49 (compound 49) hydrochloride shows a weak inhibitory effect on AAK1, BMP2K and STK16, with IC50s of 28, 63 and >100μM, respectively[1].
[1]. Asquith CRM, et al. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem. 2018;13(1):48-66.
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