DC41-SMe |
| カタログ番号GC35818 |
DC1 誘導体である DC41-SMe は、Ramos、Namalwa、および HL60/s 細胞において 18 ～ 25 pM の範囲の IC50 で細胞毒性を示します。 CC-1065 の簡略化された類似体である DC1 は、癌の標的治療のための細胞傷害性 DNA アルキル化剤の抗体コンジュゲートです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1354787-71-5
Sample solution is provided at 25 µL, 10mM.
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DC41-SMe is a DC1 derivative, shows cytotoxicity in Ramos, Namalwa, and HL60/s cells with IC50s ranging from 18-25 pM. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer[1][2].
[1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82. [2]. Kovtun YV, et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res. 2006 Mar 15;66(6):3214-21.
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