DS28120313 |
カタログ番号GC35902 |
DS28120313 (化合物 32) は、IC50 が 0.093 μM の経口ヘプシジン産生阻害剤です 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2146177-09-3
Sample solution is provided at 25 µL, 10mM.
DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM[1]. IC50: 0.093 μM (hepcidin production)[1]
DS28120313 (deliver orally; 30 mg/kg; 30 min before IL-6 administration) inhibits hepcidin production and reduces the blood hepcidin level in IL-6 induced acute inflammatory C57BL/6 mouse model[1].
[1]. Fukuda T, et al. Discovery of DS28120313 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4,6-disubstituted indazole derivatives. Bioorg Med Chem Lett. 2017 Dec 1;27(23):5252-5257.
Average Rating: 5
(Based on Reviews and 35 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *