DW14800 |
| カタログ番号GC35914 |
DW14800 は、タンパク質アルギニンメチルトランスフェラーゼ 5 (PRMT5) 阻害剤であり、IC50 は 17 nM です。 DW14800 は H4R3me2s レベルを低下させ、HNF4α の転写を強化しますが、PRMT5 の発現は変化させません。抗がん作用。
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Cas No.: 2243709-60-4
Sample solution is provided at 25 µL, 10mM.
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DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity[1]. PRMT5[1]
[1]. Zheng BN, et al. Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α. Theranostics. 2019 Apr 13;9(9):2606-2617.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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