EPZ020411 hydrochloride |
| カタログ番号GC36000 |
EPZ020411 塩酸塩は、IC50 が 10 nM の PRMT6 の選択的阻害剤であり、PRMT1 および PRMT8 よりも PRMT6 に対して >10 倍の選択性があります。 EPZ020411 塩酸塩は、がんの研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2070015-25-5
Sample solution is provided at 25 µL, 10mM.
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EPZ020411 hydrochloride is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has ＞10 fold selectivity for PRMT6 over PRMT1 and PRMT8.IC50 value: 10 nMTarget: PRMT6in vitro: EPZ020411 inhibits methylation of PRMT6 substrates in cells. EPZ020411 does-dependently inhibits H3R2 methylation in PRMT6-overexpressing cells.in vivo: EPZ020411 shows good bioavailability following subcutaneous (SC) dosing in rats making it a suitable tool for in vivo studies.
[1]. Mitchell LH, et al. Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 ToolCompound. ACS Med Chem Lett. 2015 Apr 6;6(6):655-659.
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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