LSD1-IN-6 |
カタログ番号GC36485 |
LSD1-IN-6 (化合物 4m) は、リジン特異的デメチラーゼ 1 (LSD1) の強力で可逆的な阻害剤であり、IC50 は 123 nM です。 LSD1-IN-6 は、ヒストン H3 のジメチル化 Lys4 を増加させますが、LSD1 の発現には影響しません。
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Cas No.: 2035912-43-5
Sample solution is provided at 25 µL, 10mM.
LSD1-IN-6 (Compound 4m) is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 123 nM. LSD1-IN-6 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1[1]. IC50: 123 nM (LSD1)[1]
[1]. Duan YC, et al. Discovery of resveratrol derivatives as novel LSD1 inhibitors: Design, synthesis and their biological evaluation. Eur J Med Chem. 2017 Jan 27;126:246-258.
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