PAT-048 |
| カタログ番号GC36859 |
PAT-048 は強力で選択的な経口活性オートタキシン阻害剤であり、IL-6 mRNA 発現を阻害しますが、オートタキシンタンパク質および肺線維症モデルにおける肺リゾホスファチジン酸 (LPA) 産生には影響を示しません。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1359983-15-5
Sample solution is provided at 25 µL, 10mM.
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PAT-048 is a potent, selective and orally active autotaxin inhibitor, inhibits IL-6 mRNA expression, but shows no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in lung fibrosis model. PAT-048 shows an IC50 and IC90 of 20 nM and 200 nM for autotaxin in mouse plasma. PAT-048 reduces dermal fibrosis in vivo[1][2]. IC50: 20 nM (Autotaxin, in mouse plasma)[1] IC90: 200 nM (Autotaxin, in mouse plasma)[1]
[1]. Castelino FV, et al. An Autotaxin/Lysophosphatidic Acid/Interleukin-6 Amplification Loop Drives Scleroderma Fibrosis. Arthritis Rheumatol. 2016 Dec;68(12):2964-2974. [2]. Black KE, et al. Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis. FASEB J. 2016 Jun;30(6):2435-50.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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