PF-CBP1 hydrochloride |
| カタログ番号GC36887 |
PF-CBP1 塩酸塩は、CREB 結合タンパク質ブロモドメイン (CBP BRD) の高度に選択的な阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2070014-93-4
Sample solution is provided at 25 µL, 10mM.
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PF-CBP1 hydrochloride is a highly selective inhibitor of the CREB binding protein bromodomain.Target: CREBin vitro: PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 downregulates RGS4 in neurons, a target linked to Parkinson's disease. PF-CBP1 is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC. F-CBP1 is also a potent inhibitor of EP300 (a result observed for other CBP inhibitors. [1]
[1]. Chekler EL, et al. Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities. Chem Biol. 2015 Dec 17;22(12):1588-96.
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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