Pyrazofurin |
カタログ番号GC37042 |
抗腫瘍活性を有するピリミジンヌクレオシド類似体であるピラゾフリンは、ウリジン 5'-リン酸 (UMP) シンターゼを阻害することにより、細胞増殖と細胞内の DNA 合成を阻害します。ピラゾフリンは、3 つの扁平上皮癌 (SCC) 細胞株 Hep-2、HNSCC-14B、および HNSCC-14C で 0.06 ~ 0.37 μM の IC50 を持つ、活性で高感度のオロチン酸ホスホリボシルトランスフェラーゼ阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 30868-30-5
Sample solution is provided at 25 µL, 10mM.
Pyrazofurin, a pyrimidine nucleoside analogue with antineoplastic activity, inhibits cell proliferation and DNA synthesis in cells by inhibiting uridine 5'-phosphate (UMP) synthase[1]. Pyrazofurin is an active, sensitive orotate-phosphoribosyltransferase inhibitor with IC50s between 0.06-0.37 µM in the three squamous cell carcinoma (SCC) cell lines Hep-2, HNSCC-14B and HNSCC-14C[2].
[1]. Ringer DP, et al. Alteration in de novo pyrimidine biosynthesis during uridine reversal of pyrazofurin-inhibited DNA synthesis. Neuropsychopharmacology. J Biochem Toxicol. 1991 Spring;6(1):19-27. [2]. Peters GJ, et al. Antipyrimidine effects of five different pyrimidine de novo synthesis inhibitors in three head and neck cancer cell lines. Nucleosides Nucleotides Nucleic Acids. 2018;37(6):329-339.
Average Rating: 5
(Based on Reviews and 40 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *