Cridanimod |
| カタログ番号GC38648 |
クリダニモドは、IFNα および IFNβ 発現の誘導を介して媒介される強力なプロゲステロン受容体 (PR) 活性化因子です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 38609-97-1
Sample solution is provided at 25 µL, 10mM.
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Cridanimod is a small-molecule immunomodulator and interferon inducer[1]. Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression[2].
Cridanimod (IM; 1-6 mg; twice a week) has a significantly longer survival time. Cridanimod significant increases in IFNα and -β in cridanimod-treated mice in a dose-dependent manner[1]. Animal Model: Athymic mice with hec50co cells[1]
[1]. Xenetic Biosciences Announces FDA Acceptance of Investigational New Drug Application to Initiate Phase 2 Clinical Trial of Virexxa® in Endometrial Cancer. AUGUST 19, 2016 [2]. Matthew J. Carlson, et al. Cridanimod and progestin therapy in hormone-resistant endometrial cancer. Journal of Clinical Oncology, January 30, 2017.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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