GSK 143 |
カタログ番号GC50429 |
GSK 143 は、pIC50 が 7.5 の経口的に活性で選択性の高い脾臓チロシンキナーゼ (SYK) 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1240390-27-5
Sample solution is provided at 25 µL, 10mM.
Spleen tyrosine kinase (Syk) inhibitor (pIC50 = 7.5). Also inhibits phosphorylated Erk (pIC50 = 7.1). Decreases cell number and viability in chronic lymphocytic leukemia (CCL) cell lines.
Liddle et al (2011) Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg.Med.Chem.Lett. 21 6188 PMID:21903390 |Varghese et al (2018) Highly selective SYK inhibitor, GSK143, abrogates survival signals in chronic lymphocytic leukaemia. Br.J.Haematol 182 927 PMID:28770560
Average Rating: 5
(Based on Reviews and 8 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *